Hepatocyte Liver-Assist Systems—a Clinical Update

Clinical update in liver transplantation.

There has been considerable recent progress liver transplantation (LTX). The postreperfusion syndrome has clearly defined and typically responds to vasopressin and/or methylene blue when refractory to catecholamine therapy. Diastolic dysfunction and cirrhotic cardiomyopathy are prevalent and important in LTX recipients. The high cardiovascular risk and the increasing medical complexity of the c...

Liver, Hepatocyte – Glycogen accumulation Liver, Hepatocyte – Glycogen depletion

Figure Legend: Figure 1 Glycogen accumulation–normal accumulation in hepatocytes in a female B6C3F1 mouse from a chronic study. Figure 2 Glycogen accumulation–normal mobilization of glycogen from centrilobular area in a male B6C3F1 mouse from a subchronic study. Figure 3 Glycogen accumulation–glycogen in all hepatocytes in a male B6C3F1 mouse from a subchronic study. Figure 4 Glycogen depletion...

Clinical Reviews Liver Diseases Update on Nonalcoholic Fatty Liver Disease

Nonalcoholic fatty liver disease is now recognized as the most common liver disease in the United States, with a prevalence of approximately 5% in the general population and up to 25% to 75% in patients with obesity and type II diabetes mellitus. Nonalcoholic fatty liver disease is a clinicopathologic syndrome with a wide spectrum of histologic abnormalities and clinical outcomes. Hepatic steat...

Liver, Hepatocyte – Karyomegaly

Comment: Though karyomegaly is predominantly a nuclear change, Figures 1 and 2 (arrow) show enlargement of both hepatocyte cytoplasm and nuclei. The change is throughout the hepatic lobule but is more prominent in the centrilobular areas. The increase in nuclear size is consistent with polyploidy, but in this subchronic study, the severity is significantly greater than one would expect at this ...

Liver, Hepatocyte – Hypertrophy